Tufts Digital Health Research Group

Interview Study

IRB approved interview study to understand home medication practices among older adults.

Overview

Medication adherence—defined as taking medication as prescribed—is a crucial part of aging well. Studies have shown that 50% or more of U.S. adults do not take their prescriptions as directed, and that medication nonadherence is responsible for as many as 33%-69% of hospital admissions and 125,000 deaths annually. Medication adherence often relies on the development of a medication management routine with habit formation as one of the main determinants of behavior change. Habit formation specific to medication is understudied. We conducted a survey and interview study to explore how older adults manage their medication in their homes.

Time

1 year


Role

Researcher


Team

1 principle investigator, 2 researchers


Client

Tufts Digital Health Research Group

RESEARCH PROBLEM

Medication adherence—defined as taking medication as prescribed—is a crucial part of aging well. However, 50% or more of U.S. adults do not take their prescriptions as directed, and medication nonadherence is responsible for as many as 33%-69% of hospital admissions and 125,000 deaths annually. The World Health Organization (WHO) emphasizes the importance of medication adherence, stating that, “Increasing the effectiveness of adherence interventions may have a far greater impact on the health of the population than any improvement in specific medical treatment.” There are many factors that contribute to non-adherence, such as financial barriers in purchasing medications, lack of access to healthcare, and lack of physician-patient trust. 

Narrowing down the addressable problem & patient population

Although more medications are taken at home than in hospitals and clinics combined, the impact of home medication management on medication adherence is understudied. In addition, medication adherence concern is greatest for older adults since 67% of U.S. adults 45-64 take at least one prescription drug, rising to 88.5% for those 65 and older. Older adults may also view health in general and medication adherence in particular as an important component of aging in place. For these reasons, we chose to focus on effective home medication management strategies and habit formation in relation to adherence among older adults

Medication adherence—defined as taking medication as prescribed—is a crucial part of aging well. However, 50% or more of U.S. adults do not take their prescriptions as directed, and medication nonadherence is responsible for as many as 33%-69% of hospital admissions and 125,000 deaths annually. The World Health Organization (WHO) emphasizes the importance of medication adherence, stating that, “Increasing the effectiveness of adherence interventions may have a far greater impact on the health of the population than any improvement in specific medical treatment.” There are many factors that contribute to non-adherence, such as financial barriers in purchasing medications, lack of access to healthcare, and lack of physician-patient trust. 

Narrowing down the addressable problem & patient population

Although more medications are taken at home than in hospitals and clinics combined, the impact of home medication management on medication adherence is understudied. In addition, medication adherence concern is greatest for older adults since 67% of U.S. adults 45-64 take at least one prescription drug, rising to 88.5% for those 65 and older. Older adults may also view health in general and medication adherence in particular as an important component of aging in place. For these reasons, we chose to focus on effective home medication management strategies and habit formation in relation to adherence among older adults

PROBLEM STATEMENT

How do older adults develop a home medication management strategy, what are the components of their strategies, and what factors influence adherence?

RESEARCH OBJECTIVE

Identify (1) how older adults develop home medication management strategies (2) the components of their strategies (3) factors influencing their adherence, specifically focusing on routines.

RESEARCH METHOD

Interview study

22 semi-structured interviews

After conducting a survey study on home medication practices, we wanted to conduct an interview study to talk to older adults directly about how they manage their medication in their homes.  

Semi-structured qualitative interviews using an interview guide were conducted with 22 participants on Zoom during August 2022. Each interview took around 45 minutes. Consent to participate was obtained at recruitment, and consent to record the interview was obtained at the start of the interview. Thematic analysis was performed by reviewing and coding interview recordings and transcripts.

Developing a semi-structured interview guide

The interview guide was designed to elicit information about daily routines and perceived barriers to and facilitators of adherence. The guide started out with simple, straightforward questions to more complex ones. Interview questions were designed to cover the three components to adherence —initiation, implementation, persistence— to fully address the stages of adherence. Below are some themes we addressed in each component of adherence:


Initiation (time from prescription until first dose taken):  How do they obtain their medication (pharmacy pickup or delivery)? Did they receive any medical guidance about how to be adherent?

Implementation (extent patient takes medication as prescribed): What is their current medication management routine? How did they develop it? When and where do they take their medication? How do they remember to take their medication? Do they use any devices or reminders? Where do they store medications?

Persistence (time from initiation to discontinuation of medication aka non-adherence): What events led to decreased adherence? Using a subset of the Morisky Medication Adherence scale (a validated assessment that describes medication adherence), when was the last time they forgot to take a medication?

image of interview guide

Institutional Review Board(IRB) approval

○ Study protocols were approved by Tufts University Health Sciences Institutional Review Board.

Thematic Analysis: Inductive Coding

○ Aims of the analysis were to explore and understand experiences of the participants; therefore, thematic analysis was chosen as the analytic strategy. Thematic analysis is a qualitative descriptive approach that is used to identify, analyze, and report patterns, called themes, within data. It is useful for analyzing narratives. 

○ I along with another researcher conducted inductive thematic coding. We independently replayed the interview recordings and used the transcripts to develop a list of preliminary codes, which were then reviewed by the research team and collated into potential themes until consensus was reached about the themes. I and another researcher also highlighted quotes that provided strong illustrations of the themes. Then, I with 2 other researchers, collated the themes into descriptive text and reviewed the chosen quotes to find exemplars for each theme.

RESULTS

Experience of obtaining medication (initiation)

FINDING #1

Lack of guidance on how to manage medications

Of 22 participants, over half (13) used trial and error to find their current adherence strategy; 5 participants used previous experience of helping someone else manage their medication and 4 received suggestions from a friend or family member. No participants received guidance from a medical professional about how to devise an effective medication management practice, such as where to put, how to store, or how to develop a routine around taking their prescription medications.

Implication: This lack of guidance from medical professionals presents a missed opportunity to increase medication adherence, especially with the low adherence rate in the US.

FINDING #2

Increasing mail orders and 90-day supplies 

Two thirds of participants had prescriptions delivered by mail and almost all [21/22] received a 90-day supply of medication. 

Implication: Mail order further limits opportunities for pharmacist guidance, such as how to correctly take medications, or patients to ask questions. This is further compounded by almost all participants receiving a 90-day supply.


Experience taking medication at home (implementation)

FINDING #1

Great variance in medication management

No two participants had a medication management routine that was exactly the same. This was despite some participants using similar adherence devices or taking medication at similar times. For participants who used a pill case, there was great variety in when they refilled their pill case; where they stored their pill case; and how they remembered to take their medication. For other participants, they developed unique, complex routines that included tactile triggers. One participant flipped her pill bottles and moved it across the microwave to keep track of their adherence.

Implication: Medication management is complex and is developed to fit a unique daily routine and person. What works for one person may not work well for another. 

"I came up with a scheme, where I keep the medicines on one side of my microwave, or my toaster oven. When I take it, I put it on the other side."
– Participant 4

FINDING #2

Pill case was the most popular adherence device 

Majority of participants[17/22] used a pill case.

Implication: Weekly pill cases may be popular because they provide direct feedback on whether or not someone took their medication using visual cues.

FINDING #2

Reliance on multiple triggers to remember to take medications 

For this study, we define adherence triggers as actions that are taken or objects that are encountered that help patients remember to take their medication. All (100%) participants relied on at least two triggers to remind them to take their medication, while 68% relied on three or more. Action triggers included eating a meal (50%) and getting ready for bed (25%); object triggers included a pill case (77%) and a water glass (18%). One participant who relied on three triggers – taking medication with a meal, using a pill case, and placing it on the dining table –  missed the first trigger but saw their pill case which acted as a fall back reminder.

Implication: Under some circumstances, multiple triggers served as “a safety net,” providing different avenues for medication reminders. How can we leverage this to improve adherence routines?


Underlying reasons for non-adherent behavior (persistence)

FINDING #1

Change of routine was the greatest contributor to non-adherence

The most common reason for non-adherence among participants was a change of routine[13/22], which caused an absence of a specific trigger. For example, one participant who relies on breakfast as a trigger forgets to take her medication when she skips breakfast:

Implication: Implication: How can we make an adherence strategy durable under a change in daily routine?

"If I have to go somewhere, first thing in the morning, that's a typical time when I forget. Because sometimes I don't even have time for breakfast or for one reason or another didn't get around to it. Then the next day, it's Monday, but I'm looking at the Sunday case saying, ‘Oh, I guess I forgot to take it yesterday.’ " –Participant 7

Conclusions

All participants in our study did not receive guidance from a healthcare professional about how to manage their medication or develop an adherence strategy. Given that we know many patients struggle with adherence, there may be value in guiding patients to develop an effective adherence strategy or recommend changes to make their current strategy stronger. Secondly, people develop unique – and sometimes surprisingly complex – routines to remember to take medication. For example, participants relied on multiple action and object triggers to remember to take their medication. Participants also became less adherent during the absence of usual triggers such as a change of routine. We hope to further probe what makes a trigger durable under disruptions to routines; if multiple, durable triggers lead to greater adherence; and how to guide older adults in developing a more successful medication strategy. Lastly, time-based reminders are the most common reminder mechanism in consumer medication management apps and devices, but few study participants reported using them or taking their medication at an exact time, instead relying on routines and time ranges. Medication nonadherence is a growing problem, which reminders can potentially mitigate. Our results highlight the need for research outside of time-based reminders, such as routine-based reminders, to increase medication adherence. While a small sample, the analysis suggests that there are opportunities to provide guidance to older adults in developing an adherence strategy and design better aids to adherence that leverage established daily routines.

Co-design activities

We had two co-design activities. The first revolved around understanding the overall patient experience from being prescribed a medication to adhering to their medication and identifying pain points along the way. The second focused on blue sky ideations about possible solutions addressing those pain points.

Activity 1: User Journey Map & Pain Points

Activity 2: Blue sky ideations

REFLECTIONS

Takeaways

TAKEAWAY #1

Learning how to work in a research setting

This was my first time working in a research setting. While I have done interviews in the past for design projects, this was my first time working on an interview study that was irb approved. I learned how to present our findings with scientific integrity and accuracy, learning to be critical of the strengths and weaknesses in our study and being rigorous about my writing. 

TAKEAWAY #2

Value of face-to-face interviews

The questions asked provided an in-depth look at home medication management through the participants’ experiences. Face to face interviews through Zoom enabled us to gain more insight and details that we didn't discover through our precious survey study.

Limitations

LIMITATION #1

Small sample size with older participants 

Our sample size of 22 participants is too small to draw universal conclusions. In addition, with an average age of 70 years old, many participants were not working full-time. Thus, their daily routines, mainly living stationary in their homes, are different to those of young adults or teenagers and results cannot be extrapolated to those ages. 

LIMITATION #2

Recruitment influencing representative sample

Lastly, participants were limited to those taking 1-3 medications and experiencing no cognitive decline. As participants were recruited through OSHER, most were highly educated, which is associated with higher health literacy and socioeconomic status. A more representative sample of older adults would need to include those with numerous medications with complicated schedules, those who are experiencing varying levels of decline, and those with different levels of education, which would add additional barriers to adherence.

Next Steps

STEP#1

Bigger and more diverse sample

A bigger and more diverse sample in terms of socioeconomic status will allow us to understand the different barriers people face in terms of home medication management. 

STEP #2

Change in interview guide

If we were to conduct another interview, we would want to separate participants into two groups: those who use pill cases and those who use the prescription bottle. This would allow us to ask more specific questions to each group, and we would likely learn more about differences in routine and storage, and their effect on adherence. 

STEP #3

Develop ways healthcare professionals and patients can work together in creating an effective adherence strategy

Based on our study, we learned that patients develop their adherence strategy through trial and error and do not receive help from healthcare professions. What are touchpoints in the healthcare system where interventions can happen and what would effective interventions look like?

STEP #4

Develop more effective adherence devices that are routine-based

Current medication adherence devices rely on time-based reminders. As we found in our study, most people think of their medication in the context of a routine and do not take medications at an exact time. Current devices provide constant alerts and reminders, resulting in alarm fatigue. Thus, we should consider a new medication adherence device that uses context aware reminders, reminding users only when they forget. 

Takeaways

TAKEAWAY #1

Learning how to work in a research setting

This was my first time working in a research setting. While I have done interviews in the past for design projects, this was my first time working on an interview study that was irb approved. I learned how to present our findings with scientific integrity and accuracy, learning to be critical of the strengths and weaknesses in our study and being rigorous about my writing. 

TAKEAWAY #2

Value of face-to-face interviews

The questions asked provided an in-depth look at home medication management through the participants’ experiences. Face to face interviews through Zoom enabled us to gain more insight and details that we didn't discover through our precious survey study.

Limitations

LIMITATION #1

Small sample size with older participants 

Our sample size of 22 participants is too small to draw universal conclusions. In addition, with an average age of 70 years old, many participants were not working full-time. Thus, their daily routines, mainly living stationary in their homes, are different to those of young adults or teenagers and results cannot be extrapolated to those ages. 

LIMITATION #2

Recruitment influencing representative sample

Lastly, participants were limited to those taking 1-3 medications and experiencing no cognitive decline. As participants were recruited through OSHER, most were highly educated, which is associated with higher health literacy and socioeconomic status. A more representative sample of older adults would need to include those with numerous medications with complicated schedules, those who are experiencing varying levels of decline, and those with different levels of education, which would add additional barriers to adherence.

Next Steps

STEP#1

Bigger and more diverse sample

A bigger and more diverse sample in terms of socioeconomic status will allow us to understand the different barriers people face in terms of home medication management. 

STEP #2

Change in interview guide

If we were to conduct another interview, we would want to separate participants into two groups: those who use pill cases and those who use the prescription bottle. This would allow us to ask more specific questions to each group, and we would likely learn more about differences in routine and storage, and their effect on adherence. 

STEP #3

Develop ways healthcare professionals and patients can work together in creating an effective adherence strategy

Based on our study, we learned that patients develop their adherence strategy through trial and error and do not receive help from healthcare professions. What are touchpoints in the healthcare system where interventions can happen and what would effective interventions look like?

STEP #4

Develop more effective adherence devices that are routine-based

Current medication adherence devices rely on time-based reminders. As we found in our study, most people think of their medication in the context of a routine and do not take medications at an exact time. Current devices provide constant alerts and reminders, resulting in alarm fatigue. Thus, we should consider a new medication adherence device that uses context aware reminders, reminding users only when they forget.